(October 2017)

Two meta-analyses in 2012 and 2014 suggested that there was a modest protective effect of probiotics used in late pregnancy/early infancy on the development of eczema within the first two years of life, although subsequent trials did not confirm these findings. A recent randomized trial provides further evidence of the lack of effectiveness of probiotics for eczema prevention. In this trial, 184 high-risk infants received either Lactobacillus rhamnosus GG plus inulin or inulin alone for the first six months of life. Eczema was diagnosed by age two in approximately 30 percent of the children in both groups. We suggest not giving probiotics during pregnancy and infancy for the prevention of eczema.

Pediatrics. 2017;140(3)

Comment: Studies have shown that some patient populations may benefit from probiotics though results were highly variable and inconsistent. Dietary manipulation has been investigated and except for foods that cause obvious flares, no dietary intervention was found to be helpful.


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